2023年3月8日

2023年3月8日,Volastra疗法,纽约临床阶段癌症生物科技公司专注于利用染色体不稳定(CIN),提出了系列60美元资金。圆是由北极星伙伴和拱Venture Partners,礼来公司和参与Droia Ventures Catalio Capital Management,维达,康奈尔大学,迈耶斯企业。公司打算利用其投资组合的基金支持临床开发KIF18A抑制剂以及管道的发展研究项目针对染色体不稳定的癌症。由路易斯负责人博士,奥利维尔·Elemento博士和塞缪尔·支持,医学博士,Ph.D., and led by Charles Hugh-Jones, Chief Executive Officer, and Scott Drutman MD PhD, Chief Medical Officer, Volastra Therapeutics is a clinical-stage drug discovery company focused on approaches to treating cancer by exploiting tumor vulnerability known as chromosomal instability (CIN). The company is developing and implementing new methods to exploit this vulnerability. Leveraging its proprietary CINtech platform, Volastra is advancing a novel synthetic lethal and immune-activating pipeline through both discovery and clinical stages to support future patients with cancer. Volastra also announced completion of the in-license of Amgen’s sovilnesib (AMG650), an oral, first-in-class small molecule inhibitor of KIF18A. Under the terms of the licensing agreement, the company receives an exclusive worldwide license (ex-China) to develop and commercialize sovilnesib. In return, Amgen receives an upfront mix of cash and equity, as well as downstream milestones and royalties. The drug is currently in Phase 1 for the treatment of platinum-resistant high-grade serous ovarian cancer, triple-negative breast cancer and other solid tumors with TP53 mutations. The FDA previously granted sovilnesib fast-track designation in platinum-resistant high grade serous ovarian cancer, underscoring the high unmet need in this population. Volastra recently announced a multi-year, up to $1.1 billion collaboration with Bristol Myers Squibb to drive drug discovery using CIN-based synthetic lethality approaches to induce tumor cell death. To complement both clinical and discovery efforts the company has built a partnership with Microsoft to develop artificial intelligence (AI) technologies for the high throughput histopathological identification of CIN. Volastra will advance clinical development of both sovilnesib and VLS-1488 in 2023.