2023年6月17日

甲状腺机能亢进放射性碘或手术治疗相关的死亡风险降低,根据研究提出周六在ENDO 2023年,在芝加哥的内分泌学会年会上。“甲状腺机能亢进或者甲状腺功能亢进是常见的,影响到3%的人口,和心脏和代谢与长期不良的后果。选择最佳的治疗仍不清楚,”Kristien Boelaert,医学博士,Ph.D., a professor of endocrinology from the University of Birmingham in the United Kingdom. Boelaert and colleagues identified 55,318 patients with newly diagnosed hyperthyroidism, treated with antithyroid drugs (ATD; 77.6%), radioiodine (14.6%), or thyroidectomy (7.8%) from a U.K. population-based electronic health record database for the EGRET Study. They examined all-cause mortality, major cardiovascular events (MACE: cardiovascular death, heart failure, or stroke), and post-treatment obesity. The average follow-up was roughly 12 years. Those treated with antithyroid drugs had an estimated mean survival of 12 years, according to the data. Survival increased in those treated with radioiodine by 1.7 years and thyroidectomy by 1.1 years. People treated with antithyroid drugs had an estimated 10.2% risk of MACE, which significantly increased by an additional 1.3% with radioiodine but not with thyroidectomy. These definitive treatments were associated with a significantly increased survival, despite a small increased risk for overall weight gain. For example, thyroidectomy was associated with an increased likelihood of obesity in both men and women. Radioiodine treatment led to increased obesity risk in women, but not in men. “Our findings are important and will inform decision-making processes for patients and clinicians when considering optimal treatment options and are likely to impact clinical practice guidelines in the future,” Boelaert said. Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world’s oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions. The Society has more than 18,000 members, including scientists, physicians, educators, nurses and students in 122 countries. To learn more about the Society and the field of endocrinology, visit our site at www.endocrine.org. Follow us on Twitter at @TheEndoSociety and @EndoMedia .